No information was identified in the scientific or traditional literature on the safety of V. Carnitine palmitoyltransferase was observed to increase and fatty acid synthase to decrease. In an animal model of menopause, numerous enzyme systems involved in lipid accumulation and atherosclerosis development were found to be optimized after 8 weeks on a water extract of V. album tincture reduces blood pressure and serum triglycerides at a dosage of 10 drops of mother tincture (a 1:10 alcohol extract), 3 times per day. 29 Small VAA doses improve platelet response to endogenous aggregators, without inducing aggregation themselves, whereas higher doses may induce platelet aggregation. 28 Viscum album agglutinin (VAA) induces the aggregation and activation of neutrophils, thrombocytes, and erythrocytes at a concentration of 0.1–25 µg/mL in human blood. album and contribute to its vascular and anticancer effects. Lectins that bind ribosomes and reduce their activity are known as ribosome-inactivating proteins, and lectins that bind to red blood cells and affect clotting and the release of inflammatory mediators are referred to as hemagglutinins or phytohemagglutinins. Viscotoxins are poorly absorbed in oral medications that deliver small amounts of lectins along with flavonoids and other medicinally active compounds. 27 Certain Viscum lectins are known to have toxic effects and are referred to as viscotoxins. 26 Some Viscum lectins have an affinity for endothelial cells. 25 Nanomolar concentrations of various lectins are required to affect mammalian protein synthesis. album lectins promote the release of inflammatory cytokines, contributing to anti-inflammatory effects in the heart and other tissues. They also bind to inflammatory proteins and have an impact on immune response, platelet aggregation, and inflammatory pathways in various ways specific to the lectin and the tissue. Lectins bind to glycoprotein receptors on blood and other cells. Viscum lectins are believed to have anticancer, immune-stimulating, and anti-inflammatory effects. 16 They have also been shown to reduce noradrenalin-induced aortic contractions. 14 Viscum album flavonoids have been shown to reduce tachyarrhythmias 15 and to normalize electrical conduction through the Purkinje fibers, thereby decreasing ventricular excitability. Γ-aminobutyric acid, which contributes to its hypotensive effect, but this finding has not been replicated. 13 A paper published in 1959 reported that V. 12Ĭoniferin and syringin are two phenylpropanoid glycosides believed to have vascular effects including inhibiting platelet aggregation. 11 Viscum may also have hyperglycemic and antioxidant effects, helping to protect vasculature and improve circulation. Viscum album proteins enhance insulin secretion from the pancreatic beta cells without any signs of cytotoxicity. 10īecause underlying metabolic syndrome and diabetes are leading contributors to the development of chronic vascular inflammation and heart disease, agents that improve glycemic control and vascular inflammation are important for reducing the risk of and treating heart disease. 7 Viscum may improve microcirculation 8 and protect against chemotherapy-induced damage to microcirculatory vessels 9 and heart tissue. 4, 5, 6 Its positive ionotropic effect may occur via β-adrenergic innervation, 5 and it may reduce pressure in the jugular vein and carotid arteries via muscarinic receptor blockade. 3 Viscum album may also reduce vascular resistance in the coronary arteries via promotion of nitric oxide and cyclic guanosine monophosphate. It noncompetitively inhibits Ca 2+ influx through calcium-gated channels as well as Ca 2+ mobilization from intracellular stores, both of which contribute to its vasorelaxant action. Viscum album may improve blood pressure via a variety of mechanisms. Scientific research on Viscum has led to the development of parenteral drugs, including Iscador and Helixor, both of which are used to treat leukemia and lymphoma. 2 Viscum album is also a traditional medicine for cancer and inflammation. album improves carbohydrate metabolism in cases of diabetes. Traditional herbal literature notes that V. Vitus’s dance,” motor twitching, spasm, and nerve hyperactivity. Viscum album was also used for seizures and epilepsy, 1 “St. Cardiac enlargement, valvular incompetence, angina, shortness of breath, dyspnea, edema, palpitation with exertion, inability to lie down, and other symptoms of congestive heart failure are also said to be indications for Viscum. As a vagal nerve tonic, Viscum album may help strengthen weak pulse, slow tachyarrhythmia, or enliven bradycardia. Hypertension, congestive heart failure, arrhythmia, cardiac weakness, atherosclerosis, and vascular inflammation.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |